Version 5.4
Bos taurus Protein: CDC73
Summary
InnateDB Protein IDBP-680977.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC73
Protein Name cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022205
InnateDB Gene IDBG-629557 (CDC73)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.
Predicted by orthology
Total 88 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006378 mRNA polyadenylation
GO:0008285 negative regulation of cell proliferation
GO:0010390 histone monoubiquitination
GO:0019827 stem cell maintenance
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0031648 protein destabilization
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048147 negative regulation of fibroblast proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0016593 Cdc73/Paf1 complex
Protein Structure and Domains
PDB ID
InterPro IPR007852 RNA polymerase II accessory factor, Cdc73
PFAM PF05179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BPQ8
UniProt Splice Variant
Entrez Gene 100139547
UniGene Bt.97238
RefSeq NP_001178201
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042323 DAAA02042324
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca