InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IQGAP1

Summary

InnateDB Protein

IDBP-681007.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP1

Protein Name

IQ motif containing GTPase activating protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017366

InnateDB Gene

IDBG-629586 (IQGAP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017048	Rho GTPase binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035305	negative regulation of dephosphorylation
GO:0043547	positive regulation of GTPase activity
GO:0045860	positive regulation of protein kinase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0071277	cellular response to calcium ion
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0030496	midbody
GO:0030529	ribonucleoprotein complex
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031252	cell leading edge
GO:0036057	slit diaphragm
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000593 RasGAP protein, C-terminal
IPR001202 WW domain
IPR001715 Calponin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF03836
PF00397
PF00307
PF00616

PRINTS

PIRSF

SMART

SM00015
SM00456
SM00033
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite