InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AIFM2

Summary

InnateDB Protein

IDBP-681039.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIFM2

Protein Name

Apoptosis-inducing factor 2

Synonyms

AMID;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001550

InnateDB Gene

IDBG-629629 (AIFM2)

Protein Structure

UniProt Annotation

Function

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006915	apoptotic process
GO:0008637	apoptotic mitochondrial changes
GO:0043065	positive regulation of apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF07992

PRINTS

PR00469
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJM4