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InnateDB Protein
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IDBP-681063.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMG8
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Protein Name
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hypothetical protein LOC522040
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Synonyms
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C19H17orf71;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000051930
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InnateDB Gene
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IDBG-629653 (SMG8)
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Protein Structure
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| Function |
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
8 [view]
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Molecular Function |
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| Biological Process |
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GO:0000184
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nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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GO:0045859
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regulation of protein kinase activity
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR019354
Smg8/Smg9
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| PFAM |
PF10220
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
A1A4J7
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
522040
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| UniGene |
Bt.24297
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| RefSeq |
NP_001073755
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AAFC03009910
BC126609
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| GenPept |
AAI26610
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Version 5.4