Version 5.4
Bos taurus Protein: UCHL5
Summary
InnateDB Protein IDBP-681081.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL5
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms UCH37;
Species Bos taurus
Ensembl Protein ENSBTAP00000018104
InnateDB Gene IDBG-629660 (UCHL5)
Protein Structure
UniProt Annotation
Function Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 145 interaction(s) predicted by orthology.
Predicted by orthology
Total 145 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
GO:0070628 proteasome binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0010951 negative regulation of endopeptidase activity
GO:0016579 protein deubiquitination
GO:0021670 lateral ventricle development
GO:0030901 midbrain development
GO:0048853 forebrain morphogenesis
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031011 Ino80 complex
Protein Structure and Domains
PDB ID
InterPro IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
IPR017390 Ubiquitinyl hydrolase, UCH37 type
PFAM PF01088
PRINTS PR00707
PIRSF PIRSF038120
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9XSJ0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282110
UniGene Bt.4689
RefSeq NP_776906
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF148446 BC105166
GenPept AAD31533 AAI05167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca