InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SCARA5

Summary

InnateDB Protein

IDBP-681129.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCARA5

Protein Name

Scavenger receptor class A member 5

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026158

InnateDB Gene

IDBG-629711 (SCARA5)

Protein Structure

UniProt Annotation

Function

Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0070287	ferritin receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0010468	regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0034605	cellular response to heat
GO:0034755	iron ion transmembrane transport
GO:0055072	iron ion homeostasis
GO:0070207	protein homotrimerization

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR008160 Collagen triple helix repeat
IPR017448 SRCR-like domain

PFAM

PF00530
PF01391

PRINTS

PR00258

PIRSF

SMART

SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJQ2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

516087

UniGene

Bt.30575

RefSeq

NP_001095969

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142199

GenPept

AAI42200