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InnateDB Protein
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IDBP-681206.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS5
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Protein Name
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Regulator of G-protein signaling 5
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000032130
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InnateDB Gene
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IDBG-629788 (RGS5)
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Protein Structure
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| Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
6 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0005096
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GTPase activator activity
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| Biological Process |
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0009968
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negative regulation of signal transduction
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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| PFAM |
PF00615
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| PRINTS |
PR01301
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| PIRSF |
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| SMART |
SM00315
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q3T0T8
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
540509
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| UniGene |
Bt.92767
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| RefSeq |
NP_001029879
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC102265
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| GenPept |
AAI02266
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Version 5.4