InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MCTS1

Summary

InnateDB Protein

IDBP-681214.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCTS1

Protein Name

Malignant T cell-amplified sequence 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000046356

InnateDB Gene

IDBG-629799 (MCTS1)

Protein Structure

UniProt Annotation

Function

Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up- regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0002192	IRES-dependent translational initiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0032790	ribosome disassembly
GO:0040008	regulation of growth

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0022627	cytosolic small ribosomal subunit

Protein Structure and Domains

PDB ID

InterPro

IPR002478 PUA domain
IPR004521 Uncharacterised domain CHP00451
IPR015947 PUA-like domain
IPR016437 Translation-associated RNA-binding, predicted

PFAM

PF01472

PRINTS

PIRSF

PIRSF005067

SMART

SM00359

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIE4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

508412

UniGene

RefSeq

NP_001039468

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112668

GenPept

AAI12669