Bos taurus Protein: PLAT | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-681252.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | PLAT | ||||||||||||||
Protein Name | Tissue-type plasminogen activatorTissue-type plasminogen activator chain ATissue-type plasminogen activator chain B | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000001642 | ||||||||||||||
InnateDB Gene | IDBG-629833 (PLAT) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. | ||||||||||||||
Subcellular Localization | Secreted, extracellular space. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR000001
Kringle IPR000083 Fibronectin, type I IPR000742 Epidermal growth factor-like domain IPR001254 Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain IPR013806 Kringle-like fold |
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PFAM |
PF00051
PF00039 PF00008 PF00089 |
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PRINTS |
PR00722
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PIRSF | |||||||||||||||
SMART |
SM00130
SM00058 SM00181 SM00020 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q28198 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | Q9MZF7 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 281407 | ||||||||||||||
UniGene | Bt.12302 | ||||||||||||||
RefSeq | NP_776571 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF230195 BC105348 X85800 | ||||||||||||||
GenPept | AAF79125 AAI05349 CAA59795 | ||||||||||||||