Version 5.4
Bos taurus Protein: IFNAR1
Summary
InnateDB Protein IDBP-681265.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNAR1
Protein Name Interferon alpha/beta receptor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029080
InnateDB Gene IDBG-629846 (IFNAR1)
Protein Structure
UniProt Annotation
Function Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004904 interferon receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0032729 positive regulation of interferon-gamma production
GO:0042110 T cell activation
GO:0045351 type I interferon biosynthetic process
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0051607 defense response to virus
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR015373 Interferon alpha/beta receptor, beta chain
IPR016669 Interferon alpha/beta receptor 1
PFAM PF00041
PF01108
PF09294
PRINTS
PIRSF PIRSF016567
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q04790
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282257
UniGene Bt.4557
RefSeq NP_776977
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL L06320 X68443
GenPept AAA02571 CAA48484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca