InnateDB Protein
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IDBP-68127.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NUP85
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Protein Name
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nucleoporin 85kDa
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000245544
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InnateDB Gene
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IDBG-68125 (NUP85)
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Protein Structure
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Function |
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade. {ECO:0000269PubMed:12718872, ECO:0000269PubMed:15995708, ECO:0000269PubMed:16807356}.
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Subcellular Localization |
Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011502
Nucleoporin Nup85-like
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PFAM |
PF07575
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BW27
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PhosphoSite |
PhosphoSite-Q9BW27
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TrEMBL |
J3QL54
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UniProt Splice Variant |
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Entrez Gene |
79902
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UniGene |
Hs.362817
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RefSeq |
NP_079120
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HUGO |
HGNC:8734
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OMIM |
170285
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CCDS |
CCDS32730
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HPRD |
01363
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IMGT |
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EMBL |
AC022211
AF498261
AF514995
AK022611
AK297574
AL833893
BC000697
CH471099
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GenPept |
AAH00697
AAM18528
AAM76706
BAB14130
BAG59965
CAD38749
EAW89251
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