InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.46641

Summary

InnateDB Protein

IDBP-681287.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.46641

Protein Name

discoidin domain-containing receptor 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006422

InnateDB Gene

IDBG-629865 (BT.46641)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0038062	protein tyrosine kinase collagen receptor activity

Biological Process

GO:0003416	endochondral bone growth
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010763	positive regulation of fibroblast migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030199	collagen fibril organization
GO:0030500	regulation of bone mineralization
GO:0031214	biomineral tissue development
GO:0035988	chondrocyte proliferation
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
GO:0045669	positive regulation of osteoblast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046777	protein autophosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0090091	positive regulation of extracellular matrix disassembly

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008979 Galactose-binding domain-like
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00754
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00231
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt