Version 5.4
Bos taurus Protein: TPH2
Summary
InnateDB Protein IDBP-681357.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPH2
Protein Name tryptophan hydroxylase 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027708
InnateDB Gene IDBG-629839 (TPH2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0008152 metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID
InterPro IPR002912 ACT domain
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal
PFAM PF01842
PF00351
PRINTS PR00372
PIRSF PIRSF000336
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BGX6
UniProt Splice Variant
Entrez Gene 101909180
UniGene
RefSeq XP_003582220
HUGO HGNC:20692
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012293 DAAA02012294 DAAA02012295 DAAA02012296 DAAA02012297
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca