InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DDIT4

Summary

InnateDB Protein

IDBP-681378.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDIT4

Protein Name

DNA damage-inducible transcript 4 protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000187

InnateDB Gene

IDBG-629952 (DDIT4)

Protein Structure

UniProt Annotation

Function

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0009968	negative regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0030182	neuron differentiation
GO:0032007	negative regulation of TOR signaling
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043241	protein complex disassembly
GO:0045820	negative regulation of glycolytic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051607	defense response to virus
GO:0072593	reactive oxygen species metabolic process
GO:1901216	positive regulation of neuron death
GO:1902532	negative regulation of intracellular signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR012918 RTP801-like

PFAM

PF07809

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08E62

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

529235

UniGene

Bt.2091

RefSeq

NP_001069390

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123397

GenPept

AAI23398