InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS18

Summary

InnateDB Protein

IDBP-6814.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS18

Protein Name

vacuolar protein sorting 18 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000220509

InnateDB Gene

IDBG-6812 (VPS18)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. {ECO:0000269PubMed:11382755}.

Subcellular Localization

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.

Disease Associations

Tissue Specificity

Ubiquitous. Expression was highest in heart and low in lung. {ECO:0000269PubMed:11382755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0016192	vesicle-mediated transport
GO:0046718	viral entry into host cell