Version 5.4
Bos taurus Protein: THAP1
Summary
InnateDB Protein IDBP-681408.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP1
Protein Name THAP domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010035
InnateDB Gene IDBG-629979 (THAP1)
Protein Structure
UniProt Annotation
Function DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001935 endothelial cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016605 PML body
Protein Structure and Domains
PDB ID
InterPro IPR006612 Zinc finger, C2CH-type
IPR009053 Prefoldin
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0G1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538615
UniGene Bt.46092
RefSeq NP_001029820
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102409
GenPept AAI02410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca