InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATM

Summary

InnateDB Protein

IDBP-681447.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATM

Protein Name

ataxia telangiectasia mutated

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000039884

InnateDB Gene

IDBG-629882 (ATM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004677	DNA-dependent protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032403	protein complex binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000723	telomere maintenance
GO:0001756	somitogenesis
GO:0002331	pre-B cell allelic exclusion
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007094	mitotic spindle assembly checkpoint
GO:0007292	female gamete generation
GO:0007420	brain development
GO:0007507	heart development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212	response to ionizing radiation
GO:0016310	phosphorylation
GO:0016572	histone phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0030889	negative regulation of B cell proliferation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0042159	lipoprotein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	positive regulation of neuron apoptotic process
GO:0046777	protein autophosphorylation
GO:0048599	oocyte development
GO:0051402	neuron apoptotic process
GO:0071044	histone mRNA catabolic process
GO:0071480	cellular response to gamma radiation
GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint
GO:0090399	replicative senescence

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005819	spindle

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold
IPR021668 Telomere-length maintenance and DNA damage repair

PFAM

PF00454
PF02259
PF02260
PF11640

PRINTS

PIRSF

SMART

SM00146

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite