Version 5.4
Bos taurus Protein: MAPK14
Summary
InnateDB Protein IDBP-681510.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK14
Protein Name mitogen-activated protein kinase 14A
Synonyms p38;
Species Bos taurus
Ensembl Protein ENSBTAP00000023988
InnateDB Gene IDBG-630076 (MAPK14)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 148 interaction(s) predicted by orthology.
Predicted by orthology
Total 148 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0051525 NFAT protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000902 cell morphogenesis
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0002062 chondrocyte differentiation
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007519 skeletal muscle tissue development
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010831 positive regulation of myotube differentiation
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019395 fatty acid oxidation
GO:0030316 osteoclast differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038066 p38MAPK cascade
GO:0042307 positive regulation of protein import into nucleus
GO:0042770 signal transduction in response to DNA damage
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051146 striated muscle cell differentiation
GO:0071222 cellular response to lipopolysaccharide
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090400 stress-induced premature senescence
GO:1901741 positive regulation of myoblast fusion
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000922 spindle pole
GO:0005623 cell
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008352 Mitogen-activated protein (MAP) kinase, p38
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF06293
PRINTS PR00109
PR01773
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QLR9
UniProt Splice Variant
Entrez Gene 534492
UniGene Bt.11377
RefSeq NP_001095644
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148063 DAAA02054970 DAAA02054971 DAAA02054972 DAAA02054973
GenPept AAI48064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca