Version 5.4
Bos taurus Protein: APOA2
Summary
InnateDB Protein IDBP-681572.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOA2
Protein Name Apolipoprotein A-IIApolipoprotein A-II(1-76)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012138
InnateDB Gene IDBG-630130 (APOA2)
Protein Structure
UniProt Annotation
Function May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
GO:0017129 triglyceride binding
GO:0031210 phosphatidylcholine binding
GO:0034190 apolipoprotein receptor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0055102 lipase inhibitor activity
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653 high-density lipoprotein particle receptor binding
Biological Process
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0006457 protein folding
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0009395 phospholipid catabolic process
GO:0009749 response to glucose
GO:0010873 positive regulation of cholesterol esterification
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0018158 protein oxidation
GO:0018206 peptidyl-methionine modification
GO:0030300 regulation of intestinal cholesterol absorption
GO:0031647 regulation of protein stability
GO:0032375 negative regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034370 triglyceride-rich lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034384 high-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0042742 defense response to bacterium
GO:0043085 positive regulation of catalytic activity
GO:0043691 reverse cholesterol transport
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0046340 diacylglycerol catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0060192 negative regulation of lipase activity
GO:0060621 negative regulation of cholesterol import
GO:0060695 negative regulation of cholesterol transporter activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR006801 Apolipoprotein A-II (ApoA-II)
PFAM PF04711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P81644
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505394
UniGene
RefSeq NP_001039381
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111607
GenPept AAI11608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca