InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: POU2AF1

Summary

InnateDB Protein

IDBP-681579.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2AF1

Protein Name

POU domain class 2-associating factor 1

Synonyms

BOB-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008246

InnateDB Gene

IDBG-630141 (POU2AF1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR015389 POU, class 2, associating factor 1

PFAM

PF09310

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KJA4

PhosphoSite

PhosphoSite-

TrEMBL

V6F9A7

UniProt Splice Variant

Entrez Gene

528475

UniGene

Bt.48163

RefSeq

NP_001069383

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105441 GJ062397

GenPept

AAI05442 DAA22384