InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPB41L5

Summary

InnateDB Protein

IDBP-68168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB41L5

Protein Name

erythrocyte membrane protein band 4.1 like 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263713

InnateDB Gene

IDBG-68166 (EPB41L5)

Protein Structure

UniProt Annotation

Function

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269PubMed:17920587}.

Subcellular Localization

Cytoplasm. Cell junction, adherens junction. Note=Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001839	neural plate morphogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0003382	epithelial cell morphogenesis
GO:0003383	apical constriction
GO:0006931	substrate-dependent cell migration, cell attachment to substrate
GO:0007398	ectoderm development
GO:0007492	endoderm development
GO:0007498	mesoderm development
GO:0007509	mesoderm migration involved in gastrulation
GO:0009826	unidimensional cell growth
GO:0010608	posttranscriptional regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0022408	negative regulation of cell-cell adhesion
GO:0030036	actin cytoskeleton organization
GO:0031032	actomyosin structure organization
GO:0032091	negative regulation of protein binding
GO:0032092	positive regulation of protein binding
GO:0032525	somite rostral/caudal axis specification
GO:0048318	axial mesoderm development
GO:0048319	axial mesoderm morphogenesis
GO:0048339	paraxial mesoderm development
GO:0048617	embryonic foregut morphogenesis
GO:0051894	positive regulation of focal adhesion assembly
GO:0070201	regulation of establishment of protein localization
GO:0070986	left/right axis specification
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0031252	cell leading edge
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt