InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: F11R

Summary

InnateDB Protein

IDBP-681699.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11R

Protein Name

Junctional adhesion molecule A

Synonyms

JAM1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023725

InnateDB Gene

IDBG-630243 (F11R)

Protein Structure

UniProt Annotation

Function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0016032	viral process
GO:0030855	epithelial cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9XT56