Version 5.4
Bos taurus Protein: BRCA2
Summary
InnateDB Protein IDBP-681718.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCA2
Protein Name breast cancer 2, early onset
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001311
InnateDB Gene IDBG-630223 (BRCA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0010484 H3 histone acetyltransferase activity
GO:0010485 H4 histone acetyltransferase activity
GO:0043015 gamma-tubulin binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000910 cytokinesis
GO:0001556 oocyte maturation
GO:0001833 inner cell mass cell proliferation
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008585 female gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 response to X-ray
GO:0010225 response to UV-C
GO:0010332 response to gamma radiation
GO:0030097 hemopoiesis
GO:0032465 regulation of cytokinesis
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0042127 regulation of cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043009 chordate embryonic development
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0048478 replication fork protection
GO:0051276 chromosome organization
GO:0051298 centrosome duplication
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030141 secretory granule
GO:0033593 BRCA2-MAGE-D1 complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR002093 BRCA2 repeat
IPR012340 Nucleic acid-binding, OB-fold
IPR015187 BRCA2, oligonucleotide/oligosaccharide-binding 1
IPR015188 BRCA2, oligonucleotide/oligosaccharide-binding 3
IPR015205 Tower
IPR015252 Breast cancer type 2 susceptibility protein, helical domain
IPR015525 Breast cancer type 2 susceptibility protein
PFAM PF00634
PF09103
PF09104
PF09121
PF09169
PRINTS
PIRSF PIRSF002397
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1B8X8
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:1101
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02033078
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca