InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APP

Summary

InnateDB Protein

IDBP-681747.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APP

Protein Name

Amyloid beta A4 proteinSoluble APP-betaCTF-alphaBeta-amyloid protein 42Beta-amyloid protein 40Gamma-secretase C-terminal fragment 59Gamma-secretase C-terminal fragment 57

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000045951

InnateDB Gene

IDBG-630293 (APP)

Protein Structure

UniProt Annotation

Function

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1740 interaction(s) predicted by orthology.

Predicted by orthology
Total	1740 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0019899	enzyme binding
GO:0033130	acetylcholine receptor binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding
GO:0051425	PTB domain binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0001967	suckling behavior
GO:0006378	mRNA polyadenylation
GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0006878	cellular copper ion homeostasis
GO:0006897	endocytosis
GO:0006979	response to oxidative stress
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008088	axon cargo transport
GO:0008203	cholesterol metabolic process
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0010468	regulation of gene expression
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0016199	axon midline choice point recognition
GO:0016322	neuron remodeling
GO:0016358	dendrite development
GO:0030198	extracellular matrix organization
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0043393	regulation of protein binding
GO:0045665	negative regulation of neuron differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048669	collateral sprouting in absence of injury
GO:0050803	regulation of synapse structure and activity
GO:0050885	neuromuscular process controlling balance
GO:0051124	synaptic growth at neuromuscular junction
GO:0051402	neuron apoptotic process
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis

Cellular Component

GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030134	ER to Golgi transport vesicle
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0031594	neuromuscular junction
GO:0035253	ciliary rootlet
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF12924
PF03494
PF02177
PF10515
PF12925

PRINTS

PR00203
PR00204

PIRSF

SMART

SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt