Version 5.4
Bos taurus Protein: IL16
Summary
InnateDB Protein IDBP-681814.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL16
Protein Name Pro-interleukin-16Interleukin-16
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014556
InnateDB Gene IDBG-630302 (IL16)
Protein Structure
UniProt Annotation
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). {ECO:0000250}.Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity). {ECO:0000250}.
Subcellular Localization Interleukin-16: Secreted {ECO:0000250}.Pro-interleukin-16: Cytoplasm. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006935 chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0050930 induction of positive chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR020450 Interleukin-16
PFAM PF00595
PF13180
PRINTS PR01931
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0V8R5
PhosphoSite PhosphoSite-
TrEMBL F1N1J2
UniProt Splice Variant
Entrez Gene 506314
UniGene Bt.26527
RefSeq NP_001068721
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT026153 DAAA02052339 DAAA02052340 DAAA02052341 DAAA02052342
GenPept ABG66992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca