Version 5.4
Bos taurus Protein: MYF5
Summary
InnateDB Protein IDBP-681834.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYF5
Protein Name Myogenic factor 5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000038425
InnateDB Gene IDBG-630388 (MYF5)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0001756 somitogenesis
GO:0001952 regulation of cell-matrix adhesion
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0035914 skeletal muscle cell differentiation
GO:0043010 camera-type eye development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048644 muscle organ morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0060415 muscle tissue morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002546 Myogenic basic muscle-specific protein
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR022032 Myogenic determination factor 5
PFAM PF01586
PF00010
PF12232
PRINTS
PIRSF
SMART SM00520
SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17667
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281335
UniGene Bt.102
RefSeq NP_776541
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB257294 BC146221 M95684 X52526
GenPept AAA51415 AAI46222 BAE93380 CAA36758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca