InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LIN7A

Summary

InnateDB Protein

IDBP-681836.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIN7A

Protein Name

Protein lin-7 homolog A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015103

InnateDB Gene

IDBG-630389 (LIN7A)

Protein Structure

UniProt Annotation

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0097016	L27 domain binding

Biological Process

GO:0006810	transport
GO:0006887	exocytosis
GO:0007269	neurotransmitter secretion
GO:0015031	protein transport
GO:0048489	synaptic vesicle transport
GO:0048839	inner ear development

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001478 PDZ domain
IPR004172 L27
IPR014775 L27, C-terminal
IPR017365 Lin-7 homologue

PFAM

PF00595
PF13180
PF02828

PRINTS

PIRSF

PIRSF038039

SMART

SM00228
SM00569

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32LM6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

528379

UniGene

Bt.56251

RefSeq

NP_001073070

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109509

GenPept

AAI09510