InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MVD

Summary

InnateDB Protein

IDBP-681890.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MVD

Protein Name

Diphosphomevalonate decarboxylase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015994

InnateDB Gene

IDBG-630436 (MVD)

Protein Structure

UniProt Annotation

Function

Performs the first committed step in the biosynthesis of isoprenes. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004163	diphosphomevalonate decarboxylase activity
GO:0005524	ATP binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030544	Hsp70 protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008299	isoprenoid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
IPR006204 GHMP kinase N-terminal domain
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR029765 Diphosphomevalonate decarboxylase

PFAM

PF00288
PF08544

PRINTS

PIRSF

PIRSF015950

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0P570