InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RAPGEF2

Summary

InnateDB Protein

IDBP-681912.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF2

Protein Name

Rap guanine nucleotide exchange factor (GEF) 2

Synonyms

nRap GEP; PDZ-GEF1; RA-GEF-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029739

InnateDB Gene

IDBG-630445 (RAPGEF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0030165	PDZ domain binding
GO:0030552	cAMP binding
GO:0031697	beta-1 adrenergic receptor binding
GO:0046582	Rap GTPase activator activity
GO:0050699	WW domain binding

Biological Process

GO:0001568	blood vessel development
GO:0001764	neuron migration
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0019933	cAMP-mediated signaling
GO:0021591	ventricular system development
GO:0021884	forebrain neuron development
GO:0030154	cell differentiation
GO:0031175	neuron projection development
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0032320	positive regulation of Ras GTPase activity
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045860	positive regulation of protein kinase activity
GO:0048022	negative regulation of melanin biosynthetic process
GO:0050774	negative regulation of dendrite morphogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000670	positive regulation of dendritic cell apoptotic process
GO:2001214	positive regulation of vasculogenesis
GO:2001224	positive regulation of neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000595 Cyclic nucleotide-binding domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001478 PDZ domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR018490 Cyclic nucleotide-binding-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00027
PF00618
PF00595
PF13180
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00100
SM00229
SM00228
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

F1MSG6