InnateDB Protein
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IDBP-681992.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMGB1
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Protein Name
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High mobility group protein B1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000024094
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InnateDB Gene
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IDBG-630533 (HMGB1)
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Protein Structure
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Function |
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
64 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001773
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myeloid dendritic cell activation
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GO:0002407
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dendritic cell chemotaxis
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GO:0002437
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inflammatory response to antigenic stimulus
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GO:0006265
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DNA topological change
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GO:0006288
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base-excision repair, DNA ligation
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GO:0006310
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DNA recombination
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GO:0006338
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chromatin remodeling
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0017055
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negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
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GO:0033151
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V(D)J recombination
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GO:0043065
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positive regulation of apoptotic process
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GO:0043280
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positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043388
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positive regulation of DNA binding
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050918
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positive chemotaxis
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GO:2000426
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negative regulation of apoptotic cell clearance
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Cellular Component |
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PDB ID |
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InterPro |
IPR009071
High mobility group box domain
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
P10103
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PhosphoSite |
PhosphoSite-P10103
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
282691
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UniGene |
Bt.86935
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RefSeq |
NP_788785
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102929
BT030587
M26110
X12796
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GenPept |
AAA30567
AAI02930
ABQ13027
CAA31284
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