InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: COPA

Summary

InnateDB Protein

IDBP-682060.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPA

Protein Name

coatomer subunit alpha

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005672

InnateDB Gene

IDBG-630582 (COPA)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.Xenin: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030157	pancreatic juice secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030126	COPI vesicle coat
GO:0030663	COPI-coated vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006692 Coatomer, WD associated region
IPR010714 Coatomer, alpha subunit, C-terminal
IPR016391 Coatomer alpha subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF04053
PF06957

PRINTS

PR00320

PIRSF

PIRSF003354

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q27954

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100126041

UniGene

Bt.76408

RefSeq

NP_001099115

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC153251 X96768

GenPept

AAI53252 CAA65543