Version 5.4
Bos taurus Protein: PLAU
Summary
InnateDB Protein IDBP-682069.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLAU
Protein Name Urokinase-type plasminogen activatorUrokinase-type plasminogen activator long chain AUrokinase-type plasminogen activator short chain AUrokinase-type plasminogen activator chain B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007806
InnateDB Gene IDBG-630603 (PLAU)
Protein Structure
UniProt Annotation
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016301 kinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0001666 response to hypoxia
GO:0006508 proteolysis
GO:0010469 regulation of receptor activity
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0016310 phosphorylation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0042127 regulation of cell proliferation
GO:0042730 fibrinolysis
GO:2000097 regulation of smooth muscle cell-matrix adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000001 Kringle
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
PFAM PF00051
PF00008
PF00089
PRINTS PR00722
PIRSF
SMART SM00130
SM00181
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05589
PhosphoSite PhosphoSite-
TrEMBL Q9TVA8
UniProt Splice Variant
Entrez Gene 281408
UniGene Bt.2519
RefSeq NP_776572
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF144761 BC122657 BT030737 L03546 X85801
GenPept AAA51419 AAD30301 AAI22658 ABS45053 CAA59796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca