InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TDO2

Summary

InnateDB Protein

IDBP-682119.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TDO2

Protein Name

Tryptophan 2,3-dioxygenase

Synonyms

TRPO;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014690

InnateDB Gene

IDBG-630646 (TDO2)

Protein Structure

UniProt Annotation

Function

Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR004981 Tryptophan 2,3-dioxygenase

PFAM

PF03301

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIQ5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

530397

UniGene

Bt.55173

RefSeq

NP_001039778

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112550

GenPept

AAI12551