Version 5.4
Bos taurus Protein: DUSP6
Summary
InnateDB Protein IDBP-682206.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP6
Protein Name Dual specificity protein phosphatase 6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006022
InnateDB Gene IDBG-630730 (DUSP6)
Protein Structure
UniProt Annotation
Function Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0009953 dorsal/ventral pattern formation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0042663 regulation of endodermal cell fate specification
GO:0043065 positive regulation of apoptotic process
GO:0051409 response to nitrosative stress
GO:0060420 regulation of heart growth
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PF00581
PRINTS PR01764
PIRSF PIRSF000939
SMART SM00450
SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ36
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515310
UniGene Bt.11909
RefSeq NP_001039660
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105538 BT025424
GenPept AAI05539 ABF57380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca