InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: USP12

Summary

InnateDB Protein

IDBP-682290.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP12

Protein Name

Ubiquitin carboxyl-terminal hydrolase 12

Synonyms

USP12P1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022828

InnateDB Gene

IDBG-630803 (USP12)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5D9H7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

525655

UniGene

Bt.24513

RefSeq

NP_001091528

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT030596

GenPept

ABQ13036