Version 5.4
Bos taurus Protein: NLE1
Summary
InnateDB Protein IDBP-682356.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLE1
Protein Name Notchless protein homolog 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025423
InnateDB Gene IDBG-630856 (NLE1)
Protein Structure
UniProt Annotation
Function Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001826 inner cell mass cell differentiation
GO:0007219 Notch signaling pathway
GO:0042273 ribosomal large subunit biogenesis
GO:0045930 negative regulation of mitotic cell cycle
GO:0061484 hematopoietic stem cell homeostasis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR012972 NLE
IPR017986 WD40-repeat-containing domain
IPR018910 Lipoprotein LpqB, beta-propeller domain, C-terminal
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PF08154
PF10647
PRINTS PR00319
PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58D20
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509793
UniGene Bt.22388
RefSeq NP_001014887
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021777
GenPept AAX46624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca