Version 5.4
Bos taurus Protein: RAP2C
Summary
InnateDB Protein IDBP-682395.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP2C
Protein Name Ras-related protein Rap-2c
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005408
InnateDB Gene IDBG-630912 (RAP2C)
Protein Structure
UniProt Annotation
Function Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003713 transcription coactivator activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0030336 negative regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032486 Rap protein signal transduction
GO:0061097 regulation of protein tyrosine kinase activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF00071
PF00025
PF08477
PRINTS PR00315
PR00449
PR00328
PIRSF
SMART SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DI5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515181
UniGene Bt.26628
RefSeq NP_001069168
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123730
GenPept AAI23731

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca