Version 5.4
Bos taurus Protein: MINA
Summary
InnateDB Protein IDBP-682430.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MINA
Protein Name MYC-induced nuclear antigen
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020656
InnateDB Gene IDBG-630942 (MINA)
Protein Structure
UniProt Annotation
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q8IUF8}. Nucleus, nucleolus {ECO:0000250UniProtKB:Q8IUF8}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0042254 ribosome biogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003347 JmjC domain
PFAM PF02373
PF08007
PRINTS
PIRSF
SMART SM00558
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EA24
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540466
UniGene Bt.59196
RefSeq NP_001015675
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109961 BT020745
GenPept AAI09962 AAX08762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca