InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ROS1

Summary

InnateDB Protein

IDBP-682463.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROS1

Protein Name

c-ros oncogene 1 , receptor tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000054767

InnateDB Gene

IDBG-630892 (ROS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0002066	columnar/cuboidal epithelial cell development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0010966	regulation of phosphate transport
GO:0016049	cell growth
GO:0016310	phosphorylation
GO:0030154	cell differentiation
GO:0032006	regulation of TOR signaling
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00058
PF00069
PF07714
PF00041
PF01108

PRINTS

PR00109

PIRSF

SMART

SM00135
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt