InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HPRT1

Summary

InnateDB Protein

IDBP-682476.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPRT1

Protein Name

Hypoxanthine-guanine phosphoribosyltransferase

Synonyms

HGPRT; HPRT;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019547

InnateDB Gene

IDBG-630985 (HPRT1)

Protein Structure

UniProt Annotation

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004422	hypoxanthine phosphoribosyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0052657	guanine phosphoribosyltransferase activity

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006166	purine ribonucleoside salvage
GO:0006168	adenine salvage
GO:0006178	guanine salvage
GO:0008152	metabolic process
GO:0009116	nucleoside metabolic process
GO:0032263	GMP salvage
GO:0032264	IMP salvage
GO:0043103	hypoxanthine salvage
GO:0045964	positive regulation of dopamine metabolic process
GO:0046038	GMP catabolic process
GO:0046040	IMP metabolic process
GO:0046100	hypoxanthine metabolic process
GO:0051289	protein homotetramerization