InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: POLE4

Summary

InnateDB Protein

IDBP-682528.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLE4

Protein Name

DNA polymerase epsilon subunit 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000044967

InnateDB Gene

IDBG-631036 (POLE4)

Protein Structure

UniProt Annotation

Function

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0043966	histone H3 acetylation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0008622	epsilon DNA polymerase complex

Protein Structure and Domains

PDB ID

InterPro

IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold

PFAM

PF00808
PF00125

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QQ14

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613730

UniGene

RefSeq

NP_001094695

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149592

GenPept

AAI49593