Version 5.4
Bos taurus Protein: ST3GAL6
Summary
InnateDB Protein IDBP-682539.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL6
Protein Name Type 2 lactosamine alpha-2,3-sialyltransferase
Synonyms SIAT10;
Species Bos taurus
Ensembl Protein ENSBTAP00000005868
InnateDB Gene IDBG-631044 (ST3GAL6)
Protein Structure
UniProt Annotation
Function Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008373 sialyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006486 protein glycosylation
GO:0006664 glycolipid metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0071354 cellular response to interleukin-6
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005575 cellular_component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6H8M7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 444860
UniGene Bt.68178
RefSeq NP_001002883
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ748843 BC133294
GenPept AAI33295 CAG44452

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca