InnateDB Protein
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IDBP-682652.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NFE2
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Protein Name
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Transcription factor NF-E2 45 kDa subunit
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000002043
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InnateDB Gene
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IDBG-631149 (NFE2)
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Protein Structure
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Function |
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
81 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007267
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cell-cell signaling
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GO:0030502
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negative regulation of bone mineralization
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GO:0034242
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negative regulation of syncytium formation by plasma membrane fusion
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GO:0060716
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labyrinthine layer blood vessel development
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GO:2000758
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positive regulation of peptidyl-lysine acetylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q5EAD3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
514006
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UniGene |
Bt.24217
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RefSeq |
NP_001014923
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BT020636
BT021174
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GenPept |
AAX08653
AAX31356
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