InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: VPS35

Summary

InnateDB Protein

IDBP-682719.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS35

Protein Name

Vacuolar protein sorting-associated protein 35

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003239

InnateDB Gene

IDBG-631198 (VPS35)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030904	retromer complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR005378 Vacuolar protein sorting-associated protein 35, Vps35
IPR016024 Armadillo-type fold

PFAM

PF03635

PRINTS

PIRSF

PIRSF009375

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2HJG5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

521864

UniGene

Bt.97616

RefSeq

NP_001039723

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105430

GenPept

AAI05431