Version 5.4
Bos taurus Protein: SEMA3C
Summary
InnateDB Protein IDBP-682733.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3C
Protein Name Semaphorin-3C
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008076
InnateDB Gene IDBG-631213 (SEMA3C)
Protein Structure
UniProt Annotation
Function Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
Biological Process
GO:0001755 neural crest cell migration
GO:0001756 somitogenesis
GO:0001974 blood vessel remodeling
GO:0003151 outflow tract morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003350 pulmonary myocardium development
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007507 heart development
GO:0009791 post-embryonic development
GO:0021915 neural tube development
GO:0030154 cell differentiation
GO:0060174 limb bud formation
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR016201 Plexin-like fold
PFAM PF01403
PF07679
PRINTS
PIRSF
SMART SM00630
SM00409
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7MB70
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 512660
UniGene Bt.103869
RefSeq NP_001094552
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151369
GenPept AAI51370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca