Version 5.4
Bos taurus Protein: ISL2
Summary
InnateDB Protein IDBP-682757.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISL2
Protein Name ISL LIM homeobox 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022147
InnateDB Gene IDBG-631243 (ISL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021524 visceral motor neuron differentiation
GO:0031290 retinal ganglion cell axon guidance
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR001781 Zinc finger, LIM-type
IPR009057 Homeodomain-like
PFAM PF00046
PF00412
PRINTS
PIRSF
SMART SM00389
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BM60
UniProt Splice Variant
Entrez Gene 786913
UniGene Bt.34422
RefSeq NP_001178166
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052446
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca