InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CD3E

Summary

InnateDB Protein

IDBP-682787.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3E

Protein Name

T-cell surface glycoprotein CD3 epsilon chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020859

InnateDB Gene

IDBG-631260 (CD3E)

Protein Structure

UniProt Annotation

Function

The CD3 complex mediates signal transduction.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0007166	cell surface receptor signaling pathway
GO:0031295	T cell costimulation
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0042102	positive regulation of T cell proliferation
GO:0045060	negative thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046649	lymphocyte activation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex