InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MTHFD2

Summary

InnateDB Protein

IDBP-682936.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD2

Protein Name

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialNAD-dependent methylenetetrahydrofolate dehydrogenaseMethenyltetrahydrofolate cyclohydrolase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006419

InnateDB Gene

IDBG-631408 (MTHFD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0016491	oxidoreductase activity
GO:0016787	hydrolase activity
GO:0042301	phosphate ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

PFAM

PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0P5C2