InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.22873

Summary

InnateDB Protein

IDBP-682955.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.22873

Protein Name

Tyrosine-protein kinase receptor

Synonyms

TRKA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003980

InnateDB Gene

IDBG-631386 (BT.22873)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0010465	nerve growth factor receptor activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007623	circadian rhythm
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030183	B cell differentiation
GO:0032320	positive regulation of Ras GTPase activity
GO:0042490	mechanoreceptor differentiation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048485	sympathetic nervous system development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060385	axonogenesis involved in innervation
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020777 Tyrosine-protein kinase, neurotrophic receptor

PFAM

PF01463
PF00069
PF07714

PRINTS

PR00109
PR01940
PR01939

PIRSF

SMART

SM00082
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt