InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AK3

Summary

InnateDB Protein

IDBP-682977.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK3

Protein Name

GTP:AMP phosphotransferase, mitochondrial

Synonyms

AK3L1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022789

InnateDB Gene

IDBG-631440 (AK3)

Protein Structure

UniProt Annotation

Function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255HAMAP-Rule:MF_03169}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0019205	nucleobase-containing compound kinase activity
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006172	ADP biosynthetic process
GO:0016310	phosphorylation
GO:0046033	AMP metabolic process
GO:0046039	GTP metabolic process
GO:0046041	ITP metabolic process
GO:0046051	UTP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08760